| evolutionary genetics group | ::: | institute | ::: | university | ::: |  |
| Ryszard Korona ryszard.korona@uj.edu.pl |
Professor Institute of Environmental Sciences Jagiellonian University Gronostajowa 7, 30-387 Kraków, Poland room 2.2.1 phone + 48 12 664 51 36 fax + 48 12 664 69 12 mobile + 48 510 071 693 |
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Selected publications
Students and collaborators
Research interests:
adaptation and maladaptation, functional genomics, experimental evolution
Yeast, Saccaromyces cerevisiae, a model organism in genetics and genomics.
Spontaneous mutations: rate of origin, selective value, domination.
Planned gene deletions in the analysis of genetic networks.
Molecular mechanisms of phenotypic buffering of genetic damage.
Growth, starvation, stress - genetic variation under different conditions.
Experimental evolution of laboratory populations of microorganisms.
Selected publications
Tutaj, H., E. Pogoda, K. Tomala, and R. Korona. 2018. Gene overexpression screen for chromosome instability in yeast primarily identifies cell cycle progression genes. Current Genetics. Sep 22. doi: 10.1007/s00294-018-0885-x. [Epub ahead of print]
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Plech, M., K. Tomala, H. Tutaj, DE. Piwcewicz, JA de Visser and R. Korona. 2017. Power provides protection: Genetic robustness in yeast depends on the capacity to generate energy. PLoS Genetics. 13(5):e1006768. doi: 10.1371/journal.pgen.1006768. eCollection 2017 May.
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Pieczynska, MD., Korona, R and JA de Visser. 2017. Experimental tests of host-virus coevolution in natural killer yeast strains. Journal of Evolutionary Biology. 30(4):773-781. doi: 10.1111/jeb.13044. Epub 2017 Feb 24.
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Marek, A. and R. Korona. 2016. Strong dominance of functional alleles over gene deletions in both intensely growing and deeply starved yeast cells. Journal of Evolutionary Biology. 29(9):1836-45. doi: 10.1111/jeb.12917. Epub 2016 Jun 23.
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Pieczynska, MD., D. Wloch-Salamon, R. Korona and JA de Visser. 2016. Rapid multiple-level coevolution in experimental populations of yeast killer and nonkiller strains. Evolution. 70(6):1342-53. doi: 10.1111/evo.12945. Epub 2016 May 30.
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Tomala, K., E. Pogoda, A. Jakubowska and R. Korona. 2014. Fitness costs of minimal sequence alterations causing protein instability and toxicity. Molecular Biology and Evolution. 31(3):703-7. doi: 10.1093/molbev/mst264. Epub 2013 Dec 20.
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Plech, M., JA de Visser and R. Korona. 2014. Heterosis is prevalent among domesticated but not wild strains of Saccharomyces cerevisiae. G3: Genes, Genomes, Genetics. 4(2):315-23. doi: 10.1534/g3.113.009381.
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Marek, A. and R. Korona. 2013. Restricted pleiotropy facilitates mutational erosion of major life-history traits. Evolution. 67(11):3077-86. doi: 10.1111/evo.12196. Epub 2013 Jul 19.
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Tomala, K. and R. Korona. 2013. Evaluating the fitness cost of protein expression in Saccharomyces cerevisiae. Genome Biology and Evolution. 5(11):2051-60. doi: 10.1093/gbe/evt154. Epub 2013 Oct 14.
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Pieczynska, MD., JA de Visser and R. Korona. 2013. Incidence of symbiotic dsRNA 'killer' viruses in wild and domesticated yeast. FEMS Yeast Research. 13(8):856-9. doi: 10.1111/1567-1364.12086. Epub 2013 Oct 7.
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Sendra, K., Jakubowska A. and R. Korona. 2013. Comparing the rate of growth and metabolic efficiency of yeast experiencing environmental stress or genetic damage. Acta Biochimica Polonica. 60(4):665-9.
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Jakubowska, A. and R. Korona. 2012. Epistatsis for growth rate and total metabolic flux in yeast. PLoS ONE. 7(3):e33132. doi:10.1371/journal.pone.0033132. Epub 2012 Mar 6.
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Korona, R. 2011. Gene dispensability. Current Opinion in Biotechnology. 22(4):547-551. doi: 10.1016/j.copbio.2011.04.017. Epub 2011 May 16.
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Tomala, K., M. Micinska, U. Paluchniak and R. Korona. 2011. Convergent lifespan reaction norms in the yeast cultures exposed to different environmental stresses. Journal of Evolutionary Biology. 24(2):457-61. doi: 10.1111/j.1420-9101.2010.02189.x. Epub 2010 Dec 3.
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Fudala, A. and R. Korona. 2009. Low frequency of mutations with strongly deleterious but nonlethal fitness effects. Evolution. 63(8):2164-2171. doi: 10.1111/j.1558-5646.2009.00713.x. Epub 2009 Apr 13.
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Jakubowska, A. and R. Korona. 2009. Lack of evolutionary conservation at positions important for thermal stability in the yeast ODCase protein. Molecular Biology and Evolution. 26(7):1431-4. Epub 2009 Apr 6.
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Tomala, K. and R. Korona. 2008. Alleviation of deleterious effects of protein mutation through inactivation of molecular chaperones. Molecular Genetics and Genomics. 280:409-417. doi: 10.1007/s00438-008-0374-x.
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Jasnos, L., K. Tomala, D. Paczesniak and R. Korona. 2008. Interactions between stressful environment and gene deletions alleviate the expected average loss of fitness in yeast. Genetics. 178:2105-2111.
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Tomala, K. and R. Korona. 2008. Molecular chaperones and selection against mutations. Biology Direct. 3:5, doi: 10.1186/1745-6150-3-5.
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Jasnos, L. and R. Korona. 2007. Epistatic buffering of fitness loss in yeast double deletion strains. Nature Genetics. 39:550-554.
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Bobula, J., K. Tomala, E. Jez, D. Wloch, R. H. Borts and R. Korona. 2006. Why molecular chaperones buffer mutational damage: A case study with a yeast Hsp40/70 system. Genetics. 174:937-944.
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Sliwa, P. and R. Korona. 2005. Loss of dispensable genes is not adaptive in yeast. Proceedings of National Academy of Sciences USA. 102:17670-17674.
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Jasnos, L. P. Sliwa and R. Korona. 2005. Resolution and repeatability of phenotypic assays automated growth curve analysis in yeast and bacteria. Analytical Biochemistry. 344:138-140.
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Korona, R. 2004. Experimental studies of mutational load in Saccharomyces cerevisiae. Research in Microbiology. 155:301-310.
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Sliwa, P., J. Kluz and R. Korona. 2004. Mutational load and the transition between diploidy and haploidy in experimental populations of the yeast Saccharomyces cerevisiae. Genetica. 121:285-293.
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Szafraniec, K., D. M. Wloch, P. Sliwa, R. H. Borts and R. Korona. 2003. Small fitness effects and weak genetic interactions between deleterious mutations in heterozygous loci of the yeast Saccharomyces cerevisiae. Genetical Research. 82:19-31.
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Wloch, D. M., K. Szafraniec, R. H. Borts and R. Korona. 2001. Direct estimate of the mutation rate and the distribution of fitness effects in the yeast Saccharomyces cerevisiae. Genetics. 159:441-452.
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Wloch, D. M., R. H. Borts and R. Korona. 2001. Epistatic interactions of spontaneous mutations in haploid strains of the yeast Saccharomyces cerevisiae. Journal of Evolutionary Biology. 14:310-316.
Szafraniec, K., R. H. Borts and R. Korona. 2001. Environmental stress and mutational load in diploid strains of the yeast Saccharomyces cerevisiae. Procedings of the National Academy of Sciences USA. 98:1107-1112.
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Korona, R. 1999. Genetic load of the yeast Saccharomyces cerevisiae under diverse environmental conditions. Evolution. 53:1966-1971.
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Korona, R. 1999. Unpredictable fitness transitions between haploid and diploid strains of genetically loaded yeast Saccharomyces cerevisiae. Genetics. 151:77-85.
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Nakatsu, C. H., R. Korona, R. E. Lenski, F. J. de Bruijn, T. L. Marsh and L. J. Forney. 1998. Parallel and divergent genotypic evolution in experimental populations of Ralstonia sp. Journal of Bacteriology. 180:4325-4331.
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Nakatsu, C. H., R. Korona, et al. 1997. Genetic diversity of 2,4 - dichlorophenoxyacetic acid (2,4-D) catabolic genes. In: T. Horikoshi, M. Fukuda and T. Kudo, eds. Microbial Diversity and Genetics of Biodegradation. Japan Scientific Societies Press, Tokyo. pp. 197-206.
Lenski, R. E., G. J. Velicer and R. Korona. 1997. Experimental studies on the evolution of bacteria that degrade 2,4-dichlorophenoxyacetic acid. In: T. Horikoshi, M. Fukuda and T. Kudo, eds. Microbial Diversity and Genetics of Biodegradation. Japan Scientific Societies Press, Tokyo. pp. 83-95.
Korona, R. 1996. Adaptation to structurally different environments. Proceedings of the Royal Society. B 263:1665-1669.
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Korona, R. 1996. Genetic divergence and fitness convergence under uniform selection pressure in experimental populations of bacteria. Genetics. 143:637-644.
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Korona, R. 1995. Evolution of dispersal: a humble but important example. Trends in Ecology and Evolution. 10:53-54.
Korona, R., C. H. Nakatsu, L. J. Forney and R. E. Lenski. 1994. Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat. Proceedings of the National Academy of Sciences USA. 91:9037-9041.
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Korona, R. and B. R. Levin. 1993. Phage-mediated selection and the evolution and maintenance of restriction-modification. Evolution. 47:556-575.
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Korona, R., B. Korona and B. R. Levin. 1993. Sensitivity of naturally occurring coliphages to type I and type II restriction and modification. Journal of General Microbiology. 139:1283-1290.
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Korona, R. 1991. Genetic basis of behavioral strategies. Dispersal of female flour beetles Tribolium confusum in a laboratory system. Oikos. 62:265-270.
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Korona, R. 1991. On the role of age and body size in risky animal contests. Journal of theoretical Biology. 152:165-176.
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Korona, R. 1990. Travel costs and ideal free distribution of ovipositing female flour beetles, Tribolium confusum. Animal Behaviour. 40:186-187.
Korona, R. 1989. Evolutionarily stable strategies in competition for resource intake rate maximization. II. Oviposition behavior in Tribolium confusum. Behavioral Ecology and Sociobiology. 25:201-205.
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Korona, R. 1989. Evolutionarily stable strategies in competition for resource intake rate maximization. I. The model. Behavioral Ecology and Sociobiology. 25:193-199.
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Korona, R. 1989. Ideal free distribution of unequal competitors can be determined by the form of competition. Journal of Theoretical Biology. 138:347-352.
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Korona, R., £omnicki, A. 1988. Individual differences and survival during competition: a simple theoretical model and empirical evidence for flour beetles Tribolium castaneum (Herbst). Functional Ecology. 2:330-334.
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Present and former collaborators
Katarzyna Tomala - postdoc
Hanna Tutaj - PhD
Elzbieta Pogoda - PhD
Marcin Plech - PhD (2015)
Magdalena Pieczynska - PhD (2015)
Agnieszka Marek - PhD (2015)
Agata Jakubowska - PhD (2014)
Katarzyna Tomala - PhD (2008)
Lukasz Jasnos - PhD (2007)
Piotr Sliwa - PhD (2006)
Dominika M. Wloch-Salamon - PhD (2003)
d e s i g n e d b y P a w e ³ K a p u s t a